I have both metric and imperial machines (not my lathe). Metric is favourite by far (although I am completely competent in both), but it is virtually immaterial with a dro, excepting threading as stated above.
I have used most of the different systems over the last half century, or more, and metric is very much universal (SI uits, actually).The only difference for threading is needing a conversion gear, or gears, and the cutter must be driven in reverse ready for the next cut.
Only the US uses feet and inches system as a major nation. All imperial units can be changed to metric units, but for modellers making scale models in 1:2, 1:4, and a few other scales, it might appear to be easier to scale original full sized imperial drawings.
The imperial system will be used less and less as time progresses. That is for sure! Think globally, and realise that most cars made have metric speedometers, not mph ones! Only the US distorts the otherwise almost universal metric system.
Imperial fixings and tooling will become more expensive as time progresses. Metric is already the manufacturer's choice and will be almost universal if (or when) the US were to join the rest of the world in this century.
Most, who advocate imperial, will be older or american. Many british children still only know their height and weght in imperial units – but lots don't know how many inches there are in a foot, or pounds in a stone!
Yes, be brave, go metric. I only bought imperial machines because, for me, old british iron is preferable to lesser quality chinese items.