Hi, Ian,
Is the knob you are referring to the one slightly to the left of centre of the brass lock shown in your photo – can you confirm it is screwed into the sliding part? If so, do you know what thread is used, because if you get the knobs made, this thread will also have to be cut correctly, otherwise they will not fit correctly. I would assume from the age of the lock that the thread will probably not be metric, but one of the many types of thread used in those days. It would also be good to know the length of this thread, unless you are able to cut it yourself. If it is not threaded, how is the knob attached to the slide – rivetted over? or what.
Apart from that, they seem fairly simple, and should not involve much work – how many do you need?