Fundamentally these are manual machines with CNC bolted on afterwards.
With the exception of Deckel and Bridgeport style mills it seems to have "always" been normal practice for manual mills to have restricted Y axis travel towards the column so the outer side of the table cannot be covered by the spindle centre line. I've no idea whether there are fundamental engineering reasons. Its just the way things have "always" been done.
Similar to the unreachable ends of the table at the left and right ends.
I guess it provides safe space for work-holding devices like the common step bolt and strap sets.
Whether this was intentional right from the start of vertical mill evolution or whether some mills happened to be made that way and the spare space was found useful so it became the norm I know not.
It seems clear that vertical mill design evolved from the simple drill press, which inherently has unreachable table space, rather than the planer which is able to machine over its whole table. Presumably a matter of price / performance ratio back in the early days as a simple "drill press with x-y table" layout would have been less costly to make.
Modern full on industrial Vertical Machining Centres are made so the spindle can cover pretty much the whole table. To eyes used to manual vertical mills the tables look very small. Especially in relation to the big box enclosure.
Although possibly more objectively accurate, specifying machines by the actual area covered by the spindle rather than by table size would not be a successful sales tactic!
Clive