That does depend a lot on the design of lathe. They allow two things:
– With blocks fitted with the appropriate screws, ready "levelling" of the lathe (i.e. accurate mounting so the bed is not strained).
– Clearance around the machine for removing swarf and if you use flood-coolant, facilitating draining.
Some lathes are or were designed to bolt directly to the chip-tray and stand, but these have machined pads for the lathe's feet, and an accurately-made stand.
What does your lathe's handbook say about it?