I'd not choose a keyless as my one and only chuck. Although I mostly use keyless (Albrecht and Jacobs) there are times when only a keyed chuck (various Jacobs from the quality years) will do.
First thing to remember with keyless chucks is that they need good quality drill shanks. If the shank is damaged due to spinning they won't hold well. A one time spin can be cut away, leaving a small depression to clear the jaws, and the chuck will still hold properly. But the sort of shank abuse a keyed chuck can accept won't fly.
A damaged shank creates a serious risk of damaging the chuck jaws.
Keeping a good set of drills for machine use only so they can be treated with appropriate care is best policy but frequently not fiscally possible so there is always the risk of shank damage from use in the hand drill. Especially from the crappy keyless chucks fitted to battery drills. I've yet to meet one that holds well when hammer drilling or bouncing when trying to deal with a poor, out of round, hole or local material variations. Makita standard issue currently seem to be rather poor.
A keyless chuck relies on axial pressure to maintain grip so needs a firm feed to settle into the cut without vibration or wobble. Enlarging holes can be fraught. No sneaking up. As soon as the drill vibrates loosening is likely.
Because the chuck needs axial movement of the drill to generate full grip, only a few tho' but still movement, the drill must not be allowed to bottom out in the chuck. If it does things tend to jam up and be a right pain to unjam whilst taking appropriate care not to damage the chuck. Grip on a slipping drill can be stopped by extra pressure but the resulting axial slide may bottom the shank. Best practice is to stop and refit the drill.
Shanks with flats, either 3 or 6 are chancy. Nicely machined ones seem to be OK but the general run of hex shanks on hole saws and similar will slide back. Not good.
Bottom line is a good keyless is a precision tool and should be used as such. A bad keyless is for throwing at things or, possibly, a paperweight.
Clive