Opposed piston two stroles are nothing new. The Junkers Jumo was use during WW 2 to power aircraft.
In USA, Fairbanks Morse produced an opposed piston two stroke to power submarines. Post war, the same engine design was the prime mover for diesel electric locomotives.
The Commer TS3 was another, but with the crankshaft beneath the cylinders, drivem by large rocker levers, to make the engine compact (Boxy rather than tall ) The Rolls Royce K Series of 4, 5 and 6 cylinder (And I think the Leyland L60 ) all intended for military use. (The idea was that by altering the mesh of the geartrain coupling the upper and lower crankshafts, to compression ratio could be changed so that the engine would run on whatever fuel could be found as the army moved
The Napier Deltic extended this principle so that thre were three sets of bores, set around the crankshaft, so six pistons per crankpin. In this case the object was to provide a compact power unit. 1650 bhp in an engine only a little longet than a Perkins 6.354.
In these caes the bloower was for scavenging, rather than supercharging.
General Motors produced uniflow scavenge blown two stroles (V71 and V92 Series and the much larger 647 and 701 engines for locomotives ). The 647 and subsequent engines were eventually turbocharged.
If you want really big two strokes, look at the engine that powers the Emma Maersk and her sister ship.
These are turbocjarged two strokes, deliving 108,000 horsepower at 102 rpm. The crankshaft weighs 300 tons, and the cylinder head studs are 14 feet long!
Howard