Every job needs thinking about. Are these brackets held in the vise? In a jig? Clamped to the bed?
Before dro’s, marking out and centre punching was more common. Use of manual scales on the feed handles was the usual for slot length, taking into account any backlash as appropriate.
Makes no difference which way you cut if it is a slot – unless widening it.
Dependent on job, you could pilot hole and follow through with any end mill and just side mill (depends on thickness and cutter size, of course).
Sometimes better to chain drill and clean up the slot sides with an end mill. I use whatever cutter I think is appropriate to the job. Wearing out the sides of a cutter is, to me, often better than wearing out the ends!
Depending on the precision of the job and the precision of your machine, it may be better to mill only in one direction.
Most jobs I do don’t require absolute accuracy (often the amount of clearance is not critical).
Jobs with a 25mm wide slot maybe don’t need a 25mm milling cutter. Really narrow ones may be better cut to size in one go, but with shallow cuts.
Like I said earlier, it depends on the job. If you are not relying on it as your income, who cares if you make extra cuts as long as you get the job done. Is this a work job or a hobby job? Not sure from your post.
Edited to say t’others key in faster than me!
Edited By not done it yet on 13/07/2018 15:52:14