Hi Martin,
I don't think that you would have any problems at all.
Most of my machines are 'Imperial' but I use quite a mix of imperial & metric tooling (increasingly metric – because it's cheaper here in UK). I tend to move between the two systems according to what I'm working on. If I'm working on an older machine – I'm thinking 'fractional' generally (Whit nuts & bolts etc), if I'm working on a 'published' 2.5" engine design it will probably be imperial (and I'm into thous & BA threads) but any new tooling or designs I make/design are in metric (mm) because its generally cheaper to use metric materials, fittings, taps/dies etc. these days.
I've been working on drawings for my Sentinel (that I've mentioned elsewhere – seeking a GA) this evening and I prefer to start with a full sized drawing (where 1ft = 12" ) and then scale it down to G3 (1:22.6). Once scaled (it's still in inches) I then convert the drawing to metric (mm). It's very easy to move between the two systems when you have a CAD system – or even a calculator !.
In the workshop, it's still pretty simple. I know that 1mm = 40 thou (well near enough for my purposes) – so even I can do most of the required math in my head. Working out that 0.5mm = 20thou or that 0.2mm = 8thou is really not that hard once you start doing it routinely…
So my advice is convert your drawing directly into whatever system you prefer (or need to use) BUT if it specifies (say) metric fixings – then use them. Don't try going to "near equivalents" – use the material stated but convert the 'machined' sizes to suit yourself and/or your machines
Hope this makes sense…it's getting late – so time for bed.
Regards,
IanT