I'm inclined to think there are only five or so CAD programs that are within practical reach of the hobbyist because of their price and so this ignores the free stuff that's available, much of which is good, but having said that, I've never come across a free 3D CAD that seriously challenges the ones I mention next.
Versions of Alibre, ViaCAD, TurboCAD, MoI and one or two others, can be had at reasonable rates for us to enjoy and whilst some are easier to use than others, they will get the job done and usually in quite similar ways.
Many CAD functions are similar to what we do in engineering and that's why there are tools to extrude, lathe, bevel and cut etc.
3D CAD can become easier to use when the penny finally drops and it's understood that by joining several a few shapes such as spheres and cubes and then slicing bits off them with straight or curved lines we are copying what we do in the workshop with our lathes, mills and welders. It can get more complicated, but a surprising amount of work can be done with these simple steps.
Anyone wanting to get a good understanding of 3D CAD should have a good long read of the MoI website forum. The developer, Michael Gibson (who incidentally wrote Rhino), goes to great lengths to explain how and why tools should be used in a particular way. I learned that all the 'solid' surfaces are derived from what are basically rectangular shapes that are pushed and stretched (mathematically) into more complex shapes – including spheres and made me more aware of what shapes were practical to make by certain methods.
Martin.