Hi Nigel,
Your apparently simple question has a complicated answer!
If you are making a true-scale model then mulitiplying by 2.xyz is fine. Fine for things like the size of frames/cab etc. But to make a working loco in a sensible amount of time you will want things like a boiler and various working parts to be made from stock materials (they don’t make copper tube in 1-thou increments!)
The problem is then that thicknesses and diameters are changing by different amounts to teh separation between components
Two 1/8″ components become 1/4″, but the distance between them becomes needs to increase by a little more to allow for the thickness not increasing enough. Essentially you have to re-draw the plans completely, or be prepared to check every dimension on the job.
Neil