I think a lot comes down to the job in hand as to what way you hold the parts together. Take that frame I showed above, there is a lot of mechanical location going on as well as wiring. The two round bosses are screwed on. The sides are longer than the front & back so they drop a specific amount down into the rectangular cut out in the base plate. The vertical plate has pockets milled into it to mate with tabs on the side plates and the 4 main plates all have tabs and pockets to keep them in place. It almost holds itself together and the wire just holds it tight enough to stay in place with out risking distortion from clamps or them slipping as the whole thing is tapered.
All critical surfaces which are the base, the vertical plate, round bosses and the pads that the bearing pedestals will sit on are over thickness so the whole thing can be finish machined after soldering.