If you are cash strapped and the duty is light and slow, a number 4 is only three tooth counts from the optimum of a number 5 cutter. A bit of a gap to a 50 tooth gear, but that same No.4 cutter might make a satisfactory 50 tooth gear in delrin, which might soon ‘wear in’, possibly with a bit of care. Might also depend on what each gear is on either side of the replacements.
Involute cutters are used over a certain range, so are a close enough approximation for the outliers of the range and only perfect for the median tooth size (if even that!). Ideally, a cutter for every tooth count would be best, but 8 cutters from rack to 12(?) is a compromise already. Andrew would be in a better position than me to tell you if it would work.