I use a Mac for the F360 work and PP, then stick the g code on a thumb drive, leg it to the workshop and stick it on the Win10 machine running Mach4.
I connected the steppers this morning and ran the code – everything seemed ok so I stuck a bit in and tried it with the Z height set about 50mm higher than the work, to check again. I had already turned all the feeds down to a manageable level, and I have 3 e-stops fitted at various points. I tried it for real on a piece of MDF this afternoon with no real problems, though I did pick up on the points you raise about moving to the work zero without a lead-in and not starting the spindle soon enough. I think I can sort that out in Fusion 360 for the next test piece, and as Geoff suggests, moving X and Y first before the plunge down to the work. I’ll have a look for the Z inhibit that Martin has suggested.
Right from the moment I first ran the steppers I realised just how powerful they are, so I’ve been really careful throughout. Home, limits and e-stops have all been fitted and tested, But I appreciate the warnings, thanks.