For interest, I have used holesaws to cut large holes in the region of 2 inch diameter and more in cast iron. Feed gently from the tailstock at chuck speeds of 60 rpm or less if you can get it and once the teeth are fully engaged in the component, withdraw it frequently to clear chips. If it squeals, a little oil will help, more to lubricate the side of the holesaw rather than the teeth.
On deep drilling in such sizes cut through from both sides to meet in the middle, using the pilot drill as a guide to setting it up in reverse in the chuck. Keep the plug, it could well prove useful another day.
This last point if also helpful in avoiding the snatch on breakthough in any drilling job, meeting somewhere in solid metal is much less traumatic than a grab by the drill flutes.
Regards
Brian
PS Vic I think the speed from the table for the larger drill sizes is to much too high, I suggest half those values; you also need a really solid set up to drill a 1 inch diameter hole with a twist drill; a three cornered hole is often the result as the drill flexes.