I believe that the technique with the two bearing crank, (which was less prone to breakage than the later three bearing one ) was to fit low compression pistons in 2 and 3, and high compression in 1 and 4. When the crank whipped at high revs, the compression heights became nearer equal so that each cylinder then produced, all other things being equal, equal power.
Not sure whether it was the Austin 7 or the 1172 Ford E93 engines, tuned by Colin Chapman, which brought about the 750 Club ruling that "The function of the Inlet and Exhaust ports shall not be reversed"
Howard