I use TurboCAD, which certainly was available by a single purchase rather than the open-ended, costly rental systems some software publishers now use.. I don't know if this is still the case.
The edition I have lets you draw in either orthogonal or in 3D – useful to me as I want workshop drawings (and find the more advanced 3D "modelling" hard to learn) – whereas many CAD programmes assume or force 3D-primarily. Its publishers do not give you much help tpo learn it, and its on-line "Help" pdf "book" is anything but "Help"-ful. However, some of the professionals on its User's Forum sell tutorial videos, and my copy, bought from Paul 'The CAD' Tracy, came with a step-by-step CD-based tutorial far easier to use than a video.
I do not know if the more recent editions offer CAM-file functions. I think they all do but it's something to enquire of if you intend it driving any machine-tool.
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Some use Fusion360. It is a 3D-model programme that is or was free for private use, but last time I looked its own web-site was a bit ambiguous on that point. I tried it for a while but was deterred by its blaring approach. It is based on the Internet and unless you are careful to select otherwise will save your data files there, too, by default.
A good many here use Alibre, probably thanks to an MEW tutorial a couple of years ago around a short-term free licence. Once that six months was up you had to buy the software – I don't know if one-off purchase or rented (potentially totalling much more than straight purchase). I tried it briefly but stayed with the TurboCAD I'd fully paid for. Although I closed my Alibre "account" I received unsolicited advertising from its publisher for about a year afterwards.
There are one or two users of Solid Works or Solid Edge here. The full set is an industrial programme and probably costs thousands (its web-site was implicitly trade-only), so I was surprised to see IanT's contribution above – that is a new development.
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Orthographic or Isometric (3D) first? It depends on your draughting background and intended use. If you are entering technical-drawing completely anew you might prefer the 3D-first approach. Try both and see which you prefer. I'd guess if using a 3D-printer you'd draw in 3D anyway.
One thing I would advise, is see what if any teaching materials the publishers offer. The idea of clear instructions in a printed instruction-book you can use easily and efficiently at your own pace is anathema to the IT trade! Most who offer anything at all, use videos but not everyone can learn from videos. I can't! You might find the software has a flourishing users' forum (TC does) on which you can ask advice.
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Beware the assorted "free" CAD programmes floating around the Internet. Most have little engineering contents, or do but are heavily stripped-down "trial" versions to attract customers whilst lacking the honesty to state the price for a proper version up-front. Some on inspection, offer things like managerial flow-charts and shubbery-planning – fine I suppose if you are Head Gardener for a string of stately homes.